• 主な発表論文

    孫チーム

    1. Son C., Hosoda K., Ishihara K., Bevilacqua L., Monemdjou S., Masuzaki H., Fushiki T., Harper M. E., and Nakao K.
    Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle.
    Diabetologia. 47(1):47-54 2004.
    2. Son C., Hosoda K, Matsuda J., Fujikura J., Yonemitsu S., Iwakura H., H. Masuzaki, Y. Ogawa, T. Hayashi, H. Itoh, H. Nishimura, G. Inoue, Y. Yoshimasa, Y. Yamori, and K. Nakao. Upregulation of UCP3 gene expression by fatty acids and agonists for peroxisome proliferator-activated receptors in L6 myotubes.
    Endocrinology, 142: 4189-4194, 2001.

     

    花田(礼)チーム

    1. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM.
    CLP1 links tRNA metabolism to progressive motor-neuron loss.
    Nature 495: 474-480, 2013
    2. Hanada R, Hanada T, Sigl V, Schramek D & Penninger, JM. RANKL/RANK-beyond bones.
    J Mol Med (Berl) 89: 647-56. 2011
    3. Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM.
    Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
    Nature 468: 98-102. 2010

     

    宮澤チーム

    1. Akieda-Asai S, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Yamahara K, Mutoh E, Aoyama F, Sawaguchi A, Furuya M, Miyazato M, Kangawa K, Date Y.
    Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet.
    J Lipid Res. . 54(1):85-96, 2013
    2. Hino J, Miyazawa T, Miyazato M, Kangawa K.
    Bone morphogenetic protein-3b(BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complex.
    Int J Obes (Lond).36(5):725-34, 2012
    3. Yasoda A, Komatsu Y, Chusho H, Miyazawa T, Ozasa A, Miura M, Kurihara T, Rogi T, Tanaka S, Suda M, Tamura N, Ogawa Y, Nakao K.
    Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.
    Nat. Med.10:80-86, 2004
    4. Miyazawa T, Ogawa Y, Chusho H, Yasoda A, Tamura N, Komatsu Y, Pfeifer A, Hofmann F, Nakao K.
    Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification.
    Endocrinology 143:3604-3610, 2002

     

    岩倉チーム

    1. Bando M, Iwakura H, Ariyasu H, Koyama H, Hosoda K, Adachi S, Nakao K, Kangawa K, Akamizu T.
    Overexpression of intra-islet ghrelin enhances β-cell proliferation after streptozotocin-induced β-cell injury in mice.
    Am J Physiol Endocrinol Metab. 305 (1):E140-8, 2013
    2. Bando M, Iwakura H, Ariyasu H, Hosoda H, Yamada G, Hosoda K, Adachi S, Nakao K, Kangawa K, Akamizu T.
    Transgenic overexpression of intra-islet ghrelin does not affect insulin secretion or glucose metabolism in vivo.
    Am J Physiol Endocrinol Metab. 302(4):E403-8, 2012
    3. Iwakura H, Ariyasu H, Hosoda H, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
    Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line, MGN3-1 in vitro.
    Endocrinology. . 152(7):2619-25, 2011
    4. Iwakura H, Li Y, Ariyasu H, Hosoda H, Kanamoto N, Bando M, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
    Establishment of a Novel Ghrelin-Producing Cell Line.
    Endocrinology. 151(6):2940-5, 2010
    5. Iwakura H, Hosoda K, Son C, Fujikura J, Tomita T, Noguchi M, Ariyasu H, Takaya K, Masuzaki H, Ogawa Y, Hayashi T, Inoue G, Akamizu T, Hosoda H, Kojima M, Itoh H, Toyokuni S, Kangawa K, Nakao K.
    Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice.
    J Biol Chem. 280(15):15247-56, 2005

     

    田中チーム

    1. 1. Masuda S, Tanaka T, Masuzaki H, Nakao K, Taguchi S.
    Overexpression of leptin reduces the ratio of glycolytic to oxidative enzymatic activities without changing muscle fiber types in mouse skeletal muscle.
    Biol. Pharm. Bull. 37(1): 169-173, 2014
    2. Sonoyama T, Sone M, Honda K, Taura D, Kojima K, Inuzuka M, Kanamoto N, Tamura N, Nakao K.
    Differentiation of human embryonic stem cells and human induced pluripotent stem cells into steroid-producing cells.
    Endocrinology. 153(9):4336-45, 2012.
    3. Inoue M, Konno T, Tainaka K, Nakata E, Yoshida H, Morii T.
    Positional effects of phosphorylation on the stability and morphology of tau-related amyloid fibrils,
    Biochemistry, 51(7):1396-1406, 2012
    4. Sonoyama T, Sone M, Miyashita K, Tamura N, Yamahara K, Park K, Oyamada N, Taura D, Inuzuka M, Kojima K, Honda K, Fukunaga Y, Kanamoto N, Miura M, Yasoda A, Arai H, Itoh H, Nakao K.
    Significance of adrenocorticotropin stimulation test in the diagnosis of an aldosterone-producing adenoma.
    J Clin Endocrinol Metab. 96(9):2771-8, 2011.
    5. Tomiyama K., Maeda R., Urakawa I., Yamazaki Y., Tanaka T., Ito S., Nabeshima Y., Tomita T., Odori S., Hosoda K., Nakao K., Imura A., Nabeshima Y.
    Relevant use of Klotho in FGF19 subfamily signaling in vivo.
    Proc. Natl. Acad. Sci. U.S.A. 107(4):1666-1671, 2010
    6. Sonoyama T, Tamura N, Miyashita K, Park K, Oyamada N, Taura D, Inuzuka M, Fukunaga Y, Sone M, Nakao K.
    Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide.
    FEBS Lett. 583(12):2067-70, 2009.
    7. Inoue M, Tainaka K, Hirata A, Konno T, Morii T.
    The amyloid fibrillization of phosphorylated human tau core peptides.
    Transaction of the Materials Research Society of Japan, 34, 517-520, 2009
    8. Inoue M, Hirata A, Tainaka K, Morii T, Konno T.
    Charge-pairing mechanism of phosphorylation effect upon amyloid fibrillation of human tau core peptide.
    Biochemistry, 47(45):11847-57, 2008
    9. Tanaka T., Masuzaki H., Yasue S., Ebihara K., Shiuchi T., Ishii T., Arai N., Hirata M., Yamamoto H., Hayashi T., Hosoda K., Minokoshi Y., Nakao K..
    Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed high-fat diet.
    Cell Metab. 5(5):395-402, 2007
    10. Tanaka T., Hidaka S., Masuzaki H., Yasue S., Minokoshi Y., Ebihara K., Chusho H., Ogawa Y., Toyoda T., Sato K., Miyanaga F., Fujimoto M., Tomita T., Kusakabe T., Kobayashi N., Tanioka H., Hayashi T., Hosoda K., Yoshimatsu H., Sakata T., Nakao K.
    Skeletal muscle AMPK phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification.
    Diabetes 54(8):2365-2374, 2005

     

    花田(俊)チーム

    1. Karaca E, Weitzer S, Pehlivan D, Shiraishi H, Gogakos T, Hanada T, Wiszniewski W, Withers1 M, Campbell I.M, Erdin S, Isikay S, Franco L.M, Gonzaga-Jauregui C, Gambin T, Gelowani V, Hunter J.V, Yesil G, Koparir E, Yilmaz S, Brown M, Briskin D, Hafner M, Morozov P, Farazi T.A, Bernreuther C, Glatzel M, Trattnig S, Friske J, Kronnerwetter C, Bainbridge M.N., Gezdirici A., Seven M., Muzny D.M., Boerwinkle E., Ozen M., Centers for Mendelian Genomics, Clausen T, Tuschl T, Yuksel A, Hess A, Gibbs R.A, Martinez J, Penninger J.M, Lupski J.R. Human CLP1 mutations alter tRNA biogenesis affecting both peripheral and central nervous system function.
    Cell 157:636-650, 2014
    2. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM.
    CLP1 links tRNA metabolism to progressive motor-neuron loss.
    Nature 495: 474-480, 2013
    3. Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD, Hanada T, Yoshimura A, Baltimore D, Rudensky AY.
    Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses.
    Cell 142:914-929, 2010
    4. Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Yoshimatsu H, Takahashi N, Haeseler A, Bader M, Sebnem Kilic S, Ueta Y, Pifl C, Narumiya S, Penninger JM.
    Central control of fever and female body temperature by the osteoclast differentiation factors RANKL/RANK.
    Nature 462:505-509, 2009

     

    日下部チーム

    1. Kusakabe T, Ebihara K, Sakai T, Miyamoto L, Aotani D, Yamamoto Y, Yamamoto-Kataoka S, Aizawa-Abe M, Fujikura J, Hosoda K, Nakao K.
    Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice.
    Am J Physiology Endocrinology and Metabolism 302:E924-E931, 2012
    2. Kusakabe T, Tanioka H, Ebihara K, Hirata M, Miyamoto L, Miyanaga F, Hige H, Aotani D, Fujisawa T, Masuzaki H, Hosoda K, Nakao K.
    Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet.
    Diabetologia 52:675-683, 2009
    3. Tura D*, Noguchi M* (equally contributed), Sone M, Hosoda K, Mori E, Okada Y, Takahashi K, Homma K, Oyamada N, Inuzuka M, Sonoyama T, Ebihara K, Tamura N, Itoh H, Suemori H, Nakatsuji N, Okano H, Yamanaka S, Nakao K.
    Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells.
    FEBS Lett. 583:1029-1033, 2009
    4. Ebihara K, Kusakabe T, Hirata M, Masuzaki H, Miyanaga F, Kobayashi N, Tanaka T, Chusho H, Miyazawa T, Hayashi T, Hosoda K, Ogawa Y, Depaoli AM, Fukushima M, Nakao K.
    Efficacy and Safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy.
    J Clin Endocrinol Metab 92:532-541, 2007
    5. Ebihara K*, Kusakabe T* (equally contributed), Masuzaki H, Kobayashi N, Tanaka T, Chusho H, Miyanaga F, Miyazawa T, Hayashi T, Hosoda K, Ogawa Y, Nakao K.
    Gene and Phenotype Analysis of Congenital Generalized Lipodystrophy in Japanese: A Novel Homozygous Nonsense Mutation in Seipin Gene.
    J Clin J Clin Endocrinol Metab 89: 2360-2364, 2004

     

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